Cell Signalings and the Communications in Head and Neck Cancer

HNSCC (head and neck squamous cell carcinoma) is the sixth most common neoplasm worldwide (Cripps et al., 2010). Approximately 600,000 new cases are reported each year (Cripps et al., 2010), and in the past 30 years recurrent and/ or metastatic HNSCC has had a poor prognosis (Forastiere et al., 2001; Khuri et al., 2000). More than 50% of newly diagnosed patients do not achieve complete remission, and in approximately 10% of HNSCC cases relapse with metastasis to distant organs has been reported (van Houten et al., 2000). Therefore, research focused on gaining a better understanding of this disease and the development of novel treatment strategies is required.